Long-term passive wastewater surveillance of SARS-CoV-2 for seven university dormitories in comparison to municipal surveillanceArticle Published on 2022-12-152022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition chain collected Community COVID-19 effective eight Frame Frequency increases in Passive Passive sampling peaked plant Quantitative rates of infection reaction RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 transmission Seven similarity spread of COVID-19 Surveillance Treatment university University residences Viral load Viral RNA was done wastewater Wastewater-based surveillance (WBS). [DOI] 10.1016/j.scitotenv.2022.158421 PMC 바로가기
Statistical analysis supports UTR (untranslated region) deletion theory in SARS-CoV-2Article Published on 2022-12-012022-11-16 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, [키워드] affected Analysis ancestor Asymptomatic asymptomatic patients clinical outcomes correlation Degradation deletion of the untranslated region demonstrated Deterioration driving early stage evaluate Evolution explain genetic influence Genome hospitalized patient indicated mathematical Mortality mortality rate Mutation nucleic acid nucleic acid degradation system Patient SARS-CoV-2 SARS-COV-2 infection significantly significantly more similarity strain Support Symptoms the epidemic Toxicity UTR viral genome viral toxicity viral toxicity. virulence virus virus genome was performed [DOI] 10.1080/21505594.2022.2132059 PMC 바로가기
Signs and symptoms of COVID-19 in patients with multiple sclerosisArticle Published on 2022-12-012022-11-16 Journal: European journal of neurology [Category] COVID19(2023년), SARS, 변종, [키워드] affected Ageusia alcohol Analysis Anosmia anti-CD20 therapy association chest pain clinical collected Comorbidity coronavirus disease COVID-19 COVID-19 symptom COVID-19 symptoms Delta Demyelinating diseases difference disease-modifying treatment Factor flu-like symptom Frequency greater identify Infection investigated joint less Linear regression model multiple sclerosis Neurological disorders neurological disorders. number of symptom Occurrence Odds ratio Older outcome Pain Patient Rash recognize risk factor Shortness of breath SIGN similarity smoke smoker Symptom symptoms of COVID-19 Tachycardia therapeutic approach therapy variant [DOI] 10.1111/ene.15554 PMC 바로가기
Short-term exposure of the mayfly larvae (Cloeon dipterum, Ephemeroptera: Baetidae) to SARS-CoV-2-derived peptides and other emerging pollutants: A new threat for the aquatic environmentsArticle Published on 2022-11-252022-11-15 Journal: The Science of the total environment [Category] SARS, 바이오마커, [키워드] acetylcholinesterase addition ambient aquatic environment aquatic environments Biomarker Biomarkers Cloeon Combination concentrations coronavirus dismutase DPPH ecosystem Effect evaluate evidenced Freshwater ecosystems groups hospital Impact Insects Mortality New coronavirus nitrite Non-target organisms novel novel coronavirus. organism Organisms PCA peptide peptides principal component analysis raised reduced response risk SARS-CoV-2 scavenging significantly lower similarity Spread Stress Topic Treatment viral peptide [DOI] 10.1016/j.scitotenv.2022.157813 PMC 바로가기
Tracking SARS-CoV-2 in rivers as a tool for epidemiological surveillanceArticle Published on 2022-11-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activities analysis Bacteria Caldera can be used characterized collected Concentration Contamination contributed correlated correlation COVID-19 COVID-19 cases discharge epidemiological epidemiological situation epidemiological surveillance evaluate fecal health authorities Human Human tracers impacted limit microbiologically negatively affected normalization normalized not affected plant quantified receiving reflected reported river Rivers impacted by wastewater RNase P RT-qPCR Salta SARS-CoV-2 SARS-CoV-2 surveillance significant increase similarity Support Surveillance target Viral concentration water quality water quality. [DOI] 10.1016/j.scitotenv.2022.157707 PMC 바로가기
Antigenic mapping reveals sites of vulnerability on α-HCoV spike proteinArticle Published on 2022-11-042022-11-15 Journal: Communications Biology [Category] SARS, 진단, [키워드] antigenic appear characterized conserved distal domain dominant effective epitope Epitopes feasibility HCoV-229E HCoV-NL63 highlight human coronavirus imperative N-terminal domain Neutralizing neutralizing antibody panel of antibody Protein RBD Receptor binding domain receptor binding site recognize representing reveal S protein S proteins similarity spike Spike protein subset the SARS-CoV-2 understanding Vaccine design Vaccine development [DOI] 10.1038/s42003-022-04160-8 PMC 바로가기
An outlook on potential protein targets of COVID-19 as a druggable siteArticle Published on 2022-11-012022-11-15 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] approved cause claimed clinical trial combating contagious COVID-19 COVID-19 disease Cryo-electron microscopy Delta Efficacy feature genomic help host cell host protein infecting inhibit mechanism of action MERS-CoV Mutation non-structural proteins omicron pandemic Protein Protein target proteolytic cleavage raised Repurposed drug required SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protein shown similarity spike Spike protein strain suggested the vaccine therapeutic drugs therapeutic interventions Vaccines. variants of SARS-CoV-2 viral infection virus Wuhan X-ray diffraction [DOI] 10.1007/s11033-022-07724-3 PMC 바로가기
Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic reviewArticle Published on 2022-11-012022-11-16 Journal: Annals of Clinical and Translational Neurology [Category] 변종, [키워드] ACE affected Analysis association chemokine cohort study components conditions COVID-19 cytokine signaling Enzymes evolutionary relationship expression fatigue functional annotation Genetic genetic component Genetic variant highlight HLA-A HLA-C HLA-DQA1 HLA-DRB1 immune dysfunction Inflammation investigated Mental Ontology Pathogenesis Pathway analysis Pathways performed physical Protein Proteins receptor signaling significantly similarity Symptoms syndrome systematic review T cell activation TYK2 [DOI] 10.1002/acn3.51631 PMC 바로가기
Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airwaysArticle Published on 2022-10-282022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 airway airway epithelium airways association C15orf48 cell population changes in characterized club co-expressed cohorts CTSL diagnostic workup disease severity elevated epithelial cells expressed expressing expression expression data Gene Expression gene expression pattern Goblet cell increase in indicated individual Infection lung cancer lung cancer risk modulate modulated nasal Population SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection scRNA-seq secretory cell severe disease significantly similarity smoker smoking smoking status subpopulation TMPRSS2 viral entry Viral load [DOI] 10.1038/s41598-022-17832-6 PMC 바로가기
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived CellsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] activate Activation activities activity acute respiratory syndrome betacoronaviruses Cell cellular change coronavirus coronavirus country Critical death downstream Endoplasmic reticulum enzyme ER stress examined expression of gene functions Gene Expression HCoV-OC43 Host host cell host cells host immune system Human human cell human cells imperative individual induce infect Infection inhibit interact IRE1α pathway less limit MERS-CoV MHV Middle East molecular mechanism mRNA murine OC43 Other other coronavirus pathway Prevent processed Replication required Respiratory Coronavirus respiratory syndrome coronavirus Reticulum RNase SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe respiratory disease signaling pathway similarity splice Spread Stress tested the interferon transcription factor Trigger unfolded protein response Unfolded protein response. UPR Vaccine viral replication virus XBP1 [DOI] 10.1128/mbio.02415-22 PMC 바로가기